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Laboratory and animal studies suggest GLP-1 receptor agonists may also inhibit nuclear factor-kappa B (NF-B) signaling, a key pathway in inflammatory gene expression, and reduce oxidative stress through enhanced antioxidant enzyme activity
Majumdar, R
However, 9-10% of the orforglipron-treated groups stopped treatment because of adverse events, compared with 4-5% of those receiving semaglutide
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