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If your provider is not already checking vitamin B6 levels, requesting a pyridoxal 5-phosphate (PLP) test at your next lab draw provides useful baseline data
It actually has a history of being called the California drug as it can make you skinny and stupid As a side note, for the more easily triggered individuals, I am not saying people from California are stupid
Combined with adequate protein intake (widely recommended at 1.2-1.6g per kg of body weight during GLP-1 protocols) and resistance training, the higher dose ranges may actually preserve lean mass better than lower doses, because the energy deficit is being met predominantly through fat oxidation rather than muscle catabolism
The anti-catabolic effects become particularly valuable during the caloric deficit created by Tirzepatide therapy
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