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This symptom overlap easily confuses subjective scoring tools like the Crohns Disease Activity Index (CDAI) (109)
Pharmacol Rev 54:101127 Talebi S, Bolhassani A, Azad TM, Arashkia A, Modaresi MH (2017) Immuno-stimulating peptide derived from HMGB1 is more effective than the N-terminal domain of Gp96 as an endogenous adjuvant for improvement of protein vaccines
The elegance of the single-molecule design is that all three effects rise and fall together on one predictable once-weekly curve, instead of three separate drugs each with its own half-life and interaction profile
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