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The reasoning mirrors how tissue remodeling is thought to work

This explains why some patients experience: Temporary bloating or joint discomfort from fluid shifts Increased hunger due to ghrelin pathway activation Changes in blood sugar regulation in susceptible individuals Patients with diabetes, insulin resistance, or other metabolic conditions require medical evaluation and appropriate monitoring before and during treatment

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doi: 10.1039/C9SC04309H 184 XuLMaoXImraliASyedFMutsvangwaKBerneyDet al