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Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension

Patients were randomized to receive one of six ordered sequences of the three treatment pathways: amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin, each pathway lasting 16 weeks

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This transition is reinforced by a SOX2JAKSTAT feedback loop, which sustains chromatin accessibility and resistance to AR-targeted therapies such as enzalutamide